c-Met-IN-9

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

c-Met-IN-9 

c-Met-IN-9 是一种 4-苯氧基吡啶衍生物，是一种 c-Met 激酶抑制剂，IC50 为 12 nM。c-Met-IN-9 诱导细胞凋亡 (apoptosis)，并具有抗肿瘤活性。

c-Met-IN-9

c-Met-IN-9 Chemical Structure

CAS No. : 2760326-29-0

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生物活性

c-Met-IN-9, a 4-phenoxypyridine derivative, is a c-Met kinas inhibitor with an IC50 of 12 nM. c-Met-IN-9 induces cells apoptosis, and has antitumor activities[1].

IC50 & Target[1]

c-Met

12 nM (IC50)

体外研究
(In Vitro)

c-Met-IN-9 (Compound T14) shows remarkable antiproliferative activities against MKN-45, A549 and H460 cell lines with IC50 values of 0.64 μM, 1.92 μM and 2.68 μM, respectively[1].
c-Met-IN-9 could inhibit cells colony formation, induce cells apoptosis, and inhibit cells motility[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

475.45

Formula

C25H19F2N5O3
CAS 号

2760326-29-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ju Liu, et al. Novel 4-phenoxypyridine derivatives bearing imidazole-4-carboxamide and 1,2,4-triazole-3-carboxamide moieties: Design, synthesis and biological evaluation as potent antitumor agents. Bioorg Chem. 2022 Jan 19;120:105629.

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