K783-0308

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

K783-0308 

K783-0308 是一种有效且选择性的 FLT3 和 MNK2 双重抑制剂，IC50 值分别为 680 和 406 nM。 K783-0308 抑制 MOLM-13 (IC50=10.5 µM) 和 MV-4-11 (IC50=10.4 µM) 细胞的生长。K783-0308 促进急性髓性白血病 (AML) 细胞的凋亡 (apoptosis) 并使细胞周期停滞在 G0/G1 期。

K783-0308

K783-0308 Chemical Structure

CAS No. : 422554-29-8

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生物活性

K783-0308 is a potent and selective dual inhibitor of FLT3 and MNK2 with IC50 values of 680 and 406 nM, respectively. K783-0308 inhibits the growth of MOLM-13 (IC50=10.5 µM) and MV-4-11 (IC50=10.4 µM) cells. K783-0308 promotes acute myeloid leukemia (AML) cell apoptosis and cell cycle arrests in the G0/G1 phase[1].

IC50 & Target

MNK2

406 nM (IC50)

体外研究
(In Vitro)

K783-0308 (MOLM-13, MV-4-11 cells) shows cytotoxic effect against MOLM-13 (IC50=10.5 µM) and MV-4-11 (IC50=10.4 µM) cells[1].
K783-0308 (1, 3, 10, 30 µM) promotes AML cell apoptosis and cell cycle arrests in the G0/G1 phase[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: MOLM-13, MV-4-11 cells (RPMI-1640 supplemented with streptomycin (100 µg/mL)/penicillin (100 U/mL)/ amphotericin B (0.25 µg/mL))
Concentration: 1, 3, 10, 30 µM
Incubation Time: 48 h, 72 h
Result: Promotes AML cell apoptosis and cell cycle arrested in the G0/G1 phase.

分子量

333.43

Formula

C21H23N3O
CAS 号

422554-29-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yen SC, et al. Identification of a dual FLT3 and MNK2 inhibitor for acute myeloid leukemia treatment using a structure-based virtual screening approach. Bioorg Chem. 2022, 121:105675.

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