DHA-paclitaxel(Synonyms: Taxoprexin; Docosahexaenoic acid-paclitaxel)

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DHA-paclitaxel (Synonyms: Taxoprexin; Docosahexaenoic acid-paclitaxel)

DHA-paclitaxel是一种由天然脂肪酸DHA共价连接到紫杉醇的C2′-位置组成的惰性前药。紫杉醇部分与微管蛋白结合，抑制微管的分解，从而抑制细胞分裂。与紫杉醇相比，DHA-paclitaxel更特异性地靶向肿瘤细胞，因为肿瘤细胞吸收大量天然脂肪酸作为生化前体和能量来源。

DHA-paclitaxel(Synonyms: Taxoprexin; Docosahexaenoic acid-paclitaxel)

DHA-paclitaxel Chemical Structure

CAS No. : 199796-52-6

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生物活性

DHA-paclitaxel is an inert prodrug composed of the natural fatty acid DHA covalently linked to the C2′-position of paclitaxel. The paclitaxel moiety binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. Compared to Paclitaxel, DHA-Paclitaxel targets tumor cells more specifically because tumor cells absorb large amounts of natural fatty acids for use as biochemical precursors and energy sources.

分子量

1164.38

Formula

C69H81NO15
CAS 号

199796-52-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sparreboom A, Wolff AC, Verweij J, et al. Disposition of docosahexaenoic acid-paclitaxel, a novel taxane, in blood: in vitro and clinical pharmacokinetic studies. Clin Cancer Res. 2003;9(1):151-159.

    [2]. Bradley MO, Webb NL, Anthony FH, et al. Tumor targeting by covalent conjugation of a natural fatty acid to paclitaxel. Clin Cancer Res.

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