PAD2-IN-2

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PAD2-IN-2 

PAD2-IN-2 是一种有效的 PAD2 抑制剂。PAD2-IN-2 进入 HEK293T/PAD2 细胞的 EC50 值为 5.9 μM。PAD2-IN-2 在 HEK293/PAD2 细胞中抑制组蛋白 H3 瓜氨酸化 (EC50=2.1 μM)。PAD2-IN-2 可用于癌症研究。

PAD2-IN-2

PAD2-IN-2 Chemical Structure

CAS No. : 2095107-57-4

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生物活性

PAD2-IN-2 is a potent PAD2 inhibitor. PAD2-IN-2 enters the HEK293T/PAD2 cells with an EC50 of 5.9 μM. PAD2-IN-2 inhibits histone H3 citrullination with an EC50 of 2.1 μM in HEK293/PAD2 cells. PAD2-IN-2 can be used for the research of cancer[1].

IC50 & Target[1]

PAD2

 

体外研究
(In Vitro)

PAD2-IN-2 (compound 37a; 25 μM; HEK293T/PAD2 cells) exhibits good potency with >60% occupancy in target engagement assay[1].
PAD2-IN-2 (0, 1, 5, 10, 25μM ; 72 h) enters the HEK293T/PAD2 cells with an EC50 of 5.9 μM[1].
PAD2-IN-2 (0, 1, 5, 10, 25μM, 3 h) inhibits histone H3 citrullination with an EC50 of 2.1 μM in HEK293/PAD2 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

PAD2-IN-2 (AMF30a) protects K. pneumonia pneumonia mice from Imipenem-induced mortality increase[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

466.51

Formula

C24H27FN6O3
CAS 号

2095107-57-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Muth A, et al. Development of a Selective Inhibitor of Protein Arginine Deiminase 2. J Med Chem. 2017 Apr 13;60(7):3198-3211.

    [2]. Ye C, et al. Inappropriate use of antibiotics exacerbates inflammation through OMV-induced pyroptosis in MDR Klebsiella pneumoniae infection. Cell Rep. 2021 Sep 21;36(12):109750.

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