上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。
GS-493
GS-493 是一种选择性的酪氨酸磷酸酶 SHP2 (PTPN11) 抑制剂，IC50 为 71 nM，对 SHP2 的活性比 SHP1 和 PTP1B 高 29 倍和 45 倍。 GS-493 抑制细胞运动和癌细胞生长。GS-493 具有抗肿瘤活性。
GS-493 Chemical Structure
CAS No. : 1710337-31-7
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| 生物活性 |
GS-493 is a selective protein tyrosine phosphatase SHP2 (PTPN11) inhibitor with an IC50 of 71 nM. GS-493 is 29- and 45-fold more active toward SHP2 than related SHP1 and PTP1B. GS-493 blocks cellular motility and growth of cancer cells. Antitumor activity[1]. |
IC50 & Target |
IC50: 71 nM (SHP2); 2.08 μM (SHP1); 3.17 μM (PTP1B)[1] |
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| 体外研究 (In Vitro) |
GS-493 (0.0625-10 μM) blocks hepatocyte growth factor (HGF)-stimulated epithelial-mesenchymal transition of human pancreatic adenocarcinoma (HPAF) cells[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 体内研究 (In Vivo) |
GS-493 (46 mg/kg; i.p.; daily for 27 days) inhibits tumor growth significantly in a murine xenograft model[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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| 分子量 |
510.44 |
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| Formula |
C21H14N6O8S |
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| CAS 号 |
1710337-31-7 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 参考文献 |
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