cis-Vaccenic acid(Synonyms: 顺-十八碳烯酸)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

cis-Vaccenic acid (Synonyms: 顺-十八碳烯酸) 纯度: ≥98.0%

cis-Vaccenic acid 是来自 Rhodopseudomonas capsulate 的抗病毒提取物，是 Rhodopseudomonas capsulate 的主要活性成分，cis-Vaccenic acid 可用作潜在的胎儿血红蛋白诱导剂。

cis-Vaccenic acid(Synonyms: 顺-十八碳烯酸)

cis-Vaccenic acid Chemical Structure

CAS No. : 506-17-2

规格 价格 是否有货 数量
25mg（1.77 M * 0.05 mL in Ethanol） ￥700 In-stock
50mg（1.77 M * 0.1 mL in Ethanol） ￥1100 In-stock
100mg（1.77 M * 0.2 mL in Ethanol） ￥1800 In-stock

* Please select Quantity before adding items.

生物活性

cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate[1], acts a potential fetal hemoglobin inducer[2].

体外研究
(In Vitro)

cis-Vaccenic acid (CVA) (50 μM, 70 μM and 100 μM) induces differentiation and up-regulates gamma globin synthesis in K562, JK1 and transgenic mice erythroid progenitor stem cells[2]. cis-Vaccenic acid (50 μM) also increased the percentage of benzidine positive JK-1 cell[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Differentiation Assay[2]

Cell Line: K562 cells
Concentration: 50 μM, 70 μM and 100 μM
Incubation Time: 48 and 120 hours
Result: Induced differentiation appeared to be concentration dependent in K562 cells with 50 μM CVA being the most effective concentration with more than 20% of the K562 cells showing positive for Benzidine stain after 48 h of incubation with CVA.

分子量

282.46

Formula

C18H34O2
CAS 号

506-17-2
中文名称

顺-十八碳烯酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
参考文献

  • [1]. H Hirotani, et al. Inactivation of T5 phage by cis-vaccenic acid, an antivirus substance from Rhodopseudomonas capsulata, and by unsaturated fatty acids and related alcohols. FEMS Microbiol Lett. 1991 Jan 1;61(1):13-7.

    [2]. Idowu A Aimola, et al. Cis-vaccenic acid induces differentiation and up-regulates gamma globin synthesis in K562, JK1 and transgenic mice erythroid progenitor stem cells. Eur J Pharmacol. 2016 Apr 5;776:9-18.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

发表回复