CJJ300

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CJJ300 

CJJ300 是一个转化生长因子-β (TGF-β) 抑制剂， IC50 值为5.3 µM。CJJ300 通过阻断 TGF-β-TβR-I-TβR-II signaling complex 的形成来抑制 TGF-β signaling。

CJJ300

CJJ300 Chemical Structure

CAS No. : 1807631-83-9

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生物活性

CJJ300 is a transforming growth factor-β (TGF-β) inhibitor with an IC50 of 5.3 µM. CJJ300 inhibits TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II signaling complex[1].

IC50 & Target

IC50: 5.3 µM (TGF-β1-induced luciferase)[1]
体外研究
(In Vitro)

CJJ300 disturbs protein-protein interactions and prevents TGF-β receptor dimerization (IC50 = 23.6 ± 5.8 µM)[1].
CJJ300 (0-80 µM, 2 h) inhibits the phosphorylation of intracellular mediators in the downstream TGF-β signaling pathways, and suppresses the expression of markers of EMT (epithelial-mesenchymal transition) without cytotoxicity[1].
CJJ300 suppresses TGF-β induced cell migration[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Human A549 lung epithelial cells
Concentration: 20, 40, and 80 µM
Incubation Time: 2 h
Result: Significantly attenuated the increasement of P-Smad2/Smad3, P-Erk1/2 and P-Akt induced by TGF-β. Down regulated the expression of EMT-associated proteins, including fibronectin, α-SMA and MMP-2 in a dose-dependent manner.

分子量

435.60

Formula

C30H33N3
CAS 号

1807631-83-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Han Wu, et al. The development of a novel transforming growth factor-β (TGF-β) inhibitor that disrupts ligand-receptor interactions. Eur J Med Chem. 2020 Mar 1;189:112042.

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