上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
ATX inhibitor 13
ATX inhibitor 13 (compound 10c) 是一种口服有效的 ATX 抑制剂,其IC50 为 3.4 nM。ATX inhibitor 13 抑制 RAW264.7 细胞的增殖和迁移,诱导细胞凋亡和 G2 期阻滞。ATX inhibitor 13 抑制肿瘤细胞集落形成。
ATX inhibitor 13 Chemical Structure
CAS No. : 2485779-34-6
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生物活性 |
ATX inhibitor 13 (10c) is an orally active and potent ATX inhibitor, with an IC50 of 3.4 nM. ATX inhibitor 13 inhibits proliferation and migration, and induces apoptosis and G2 phase arrest in RAW264.7 cells. ATX inhibitor 13 suppresses tumor cell colony formation[1]. |
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IC50 & Target |
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体外研究 (In Vitro) |
ATX inhibitor 13 (compound 10c) (0-20 μM, 72 h) shows cytotoxicity and anti-proliferative activity against MCF-7, MDA-MB-231, A549, NCI-H1581, H2228, Hep3B, and RAW264.7 cells[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay
Apoptosis Analysis
Cell Cycle Analysis
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体内研究 (In Vivo) |
ATX inhibitor 13 (compound 10c) (C57BL/6J mice, 0-1000 mg/kg, Orally, once) has an acceptable safety profile[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
596.55 |
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Formula |
C31H35Cl2N5O3 |
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CAS 号 |
2485779-34-6 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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