Tubulin inhibitor 16

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Tubulin inhibitor 16 

Tubulin inhibitor 16 是一种有效的 tubulin 抑制剂。Tubulin inhibitor 16 显示出抗增殖活性。Tubulin inhibitor 16 在 HepG2 细胞中显示出细胞毒性。

Tubulin inhibitor 16

Tubulin inhibitor 16 Chemical Structure

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生物活性

Tubulin inhibitor 16 is a potent tubulin inhibitor. Tubulin inhibitor 16 shows antiproliferative activity. Tubulin inhibitor 16 shows cytotoxicity in HepG2 cells[1].

体外研究
(In Vitro)

Tubulin inhibitor 16 (compound 2) (0-25 µM, 24 h followed by a 72 h compound-free incubation period) shows antiproliferative activity with IC50s of 1.43, 0.19, 2.33, 0.58, 0.83, 0.20, >25 µM for MCF7, MDA-MB-231, HepG2, SNU423, A549, HCT116, THLE-3 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MCF7, MDA-MB-231, HepG2, SNU423, A549, HCT116 cells
Concentration: 0-50 µM
Incubation Time: 96 h
Result: Showed antiproliferation activity with IC50s of 0.75, 0.17, 3.12, 0.41, 0.37, 0.22 µM for MCF7, MDA-MB-231, HepG2, SNU423, A549, HCT116 cells, respectively.

Cell Cytotoxicity Assay[1]

Cell Line: HepG2 cells
Concentration: 0.5, 1 µM
Incubation Time: 14 days
Result: Showed no colonies were apparent when cells were treated with 0.5 or 1 µM.

分子量

269.27

Formula

C16H12FNO2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Elhemely MA,et al. SAR of Novel 3-Arylisoquinolinones: meta-Substitution on the Aryl Ring Dramatically Enhances Antiproliferative Activity through Binding to Microtubules. J Med Chem. 2022 Mar 24;65(6):4783-4797.

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