KRAS inhibitor-12

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

KRAS inhibitor-12 

KRAS inhibitor-12 (compound 6-1) 是一种有效的 KRAS G12C 抑制剂，IC50 为 0.537 µM。KRAS inhibitor-12 在 MIA PaCA-2，A549 细胞中显示出 p-ERK 抑制活性，IC50s 分别为 1.3，3.7 µM。 KRAS inhibitor-12 具有研究胰腺癌，结直肠癌和肺癌的潜力。

KRAS inhibitor-12

KRAS inhibitor-12 Chemical Structure

CAS No. : 2230874-00-5

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生物活性

KRAS inhibitor-12 (compound 6-1) is a potent KRAS G12C inhibitor with an IC50 of 0.537 µM. KRAS inhibitor-12 shows p-ERK inhibition activities with IC50s of 1.3, 3.7 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-12 has the potential for the research of pancreatic, colorectal, and lung cancers[1].

IC50 & Target[1]

KRas G12C

0.537 μM (IC50)

分子量

452.33

Formula

C19H16Cl2FN5OS
CAS 号

2230874-00-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2

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